Reference of 2186-92-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2186-92-7, name is P-anisaldehyde dimethyl acetal belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a stirred benzaldehyde dimethyl acetal 1a solution of (15 mmol) was added a freshly prepared MgI2 etherate (1.5 mmol, 1.0M in Et2O/PhMe) at room temperature, followed by addition of trimethylsilyl cyanide (18 mmol). The resulting reaction mixture was stirred at room temperature for 3.0 h. chromatographic purification of the crude producton silica gel gave the 2-phenyl-2-methoxyacetonitrile 2a in 95% yield.
The synthetic route of P-anisaldehyde dimethyl acetal has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Hua; Pan, Haokun; Meng, Xiangwei; Zhang, Xingxian; Synthetic Communications; vol. 50; 5; (2020); p. 684 – 691;,
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