Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H11ClF3NO
Intermediate 26 {[5-(4-bromophenyl)-2-thienyl]methyl}methyl({4[(trifluoromethyl)oxy]phenyl}methyl)amine (1-[5-(4-bromophenyl)-2-thienyl]-N-methyI-N-({4-[(trifluoromethyl)oxy]phenyl}methyl)methanamine). To a solution of 0.3 g of Intermediate 25 and 0.26 g of Intermediate 1 in 8.5 ml of DCE under N2 atmosphere were added dropwise 0.226 ml of Et3N and 0.342 g of NaHB(AcO)3 consecutively. The mixture was stirred overnight at room temperature and 1 N NaOH was added. The resulting mixture was extracted with CH2CI2, the combined organic layers were dried over Na2SO4, filtered and concentrated to dryness. The crude was purified by chromatography on silica gel eluting with EtOAc-Hex 0:100 to 10:90 to afford 0.383 g of the desired compound with 10% of the starting aldehyde. This mixture was re-purified on silica gel eluting with EtOAc-Hex 0:100 to 10:90 to afford 0.348 g (67%) of the title compound as a colourless oil.1H NMR (delta, ppm, CDCI3): 7.47 (dd, 4H); 7.42 (d, 2H); 7.18 (d, 2H); 7.15 (d, 1 H); 6.90 (d, 1 H); 3.75 (s, 2H); 3.58 (s, 2H); 2.28 (s, 3H). [ES MS] m/z: 456 (MH+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXO GROUP LIMITED; BUENO-CALDERON, Jose Maria; FERNANDEZ-MOLINA, Jorge; LEON-DIAZ, Maria Luisa; MALLO-RUBIO, Araceli; MANZANO-CHINCHON, M Pilar; WO2010/81904; (2010); A1;,
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