Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121588-79-2, name is trans-4-Methoxycyclohexanamine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H15NO
Example 660: 2-[3-(5-chloro-2-{[trans-4-methoxycyclohexyl]amino}pyrimidin-4-yl)-5-oxo- 5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl]-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]acetamide (3567) DIPEA (59.9 muIota, 0.343 mmol) was added to a stirred solution of (S)-2-(3-(2,5-dichloropyrimidin- 4-yl)-5-oxo-5H-pyrrolo[3^-b]pyridin-6(7H)-yl)-N-(2-hydroxy-1-(m-tolyl)ethyl)acetarnide (80 mg, 0.137 mmol) and (1 r,4r)-4-methoxycyclohexanamine (26.6 mg, 0.206 mmol) in dioxane (1 mL) under nitrogen. The mixture was heated to 90 C and stirred for 16 h. The mixture was allowed to cool to room temperature and was diluted with EtOAc (20 mL) and water (20 mL). The phases were separated and the aqueous layer was extracted with EtOAc (2 x 20 mL). The combined organic extracts were washed with brine (60 mL), dried (MgS0 ) and concentrated. The crude product was purified by chromatography (SiO2, 24 g column, 0-10% MeOH in DCM) to afford a beige solid. The product was loaded onto a column packed with SCX (0.5 g) in MeOH. The column was washed with MeOH and the product eluted with 0.7 M ammonia in MeOH. The resulting mixture was concentrated in vacuo to afford the title compound (52 mg, 66.4 %) as a beige solid. 1 H NMR (DMSO-d6, 400 MHz) delta 9.09 (1 H, s), 8.54 (1 H, d), 8.48 (1 H, s (br)), 8.40 (1 H, d), 7.62 (1 H, s (br)), 7.21 (1 H, t), 7.15 – 7.08 (2H, m), 7.07 – 7.03 (1 H, m), 4.91 (1 H, t), 4.88 – 4.80 (1 H, m), 4.64 (2H, s), 4.34 (1 H, d), 4.29 (1 H, d), 3.77 – 3.62 (1 H, m), 3.61 – 3.50 (2H, m), 3.22 (3H, s), 3.17 – 3.05 (1 H, m), 2.29 (3H, s), 2.10 – 1.84 (4H, m), 1.41 – 1.24 (2H, m), 1.24 – 1.11 (2H, m). LCMS: [M+H]+ = 565.
According to the analysis of related databases, 121588-79-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; BERDINI, Valerio; BUCK, Ildiko Maria; DAY, James Edward Harvey; GRIFFITHS-JONES, Charlotte Mary; HEIGHTMAN, Thomas Daniel; HOWARD, Steven; MURRAY, Christopher William; NORTON, David; O’REILLY, Marc; WOOLFORD, Alison Jo-Anne; COOKE, Michael Liam; COUSIN, David; ONIONS, Stuart Thomas; SHANNON, Jonathan Martin; WATTS, John Paul; (867 pag.)WO2017/68412; (2017); A1;,
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