Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6850-60-8, name is (4-Ethoxyphenyl)methanamine, A new synthetic method of this compound is introduced below., Safety of (4-Ethoxyphenyl)methanamine
General procedure: benzylamines (1, 0.2 mmol), 1,3-dicarbonyl derivatives (2,0.3 mmol), NIS (0.4 mmol), TBHP (0.6 mmol), Na2CO3 (0.4 mmol) were mixed under N2 atmosphere in 2 mL DMA. The reaction tube was heated in an oil bath at 50 C for 16 hours. After completion of the reaction, the reaction mixture was extracted with EtOAc (15 mL × 3), and the solvent was removed under reduced pressure. The remaining crude product was then purified through column chromatography using silica gel (ethyl acetate/petroleum ether = 1/10) to afford 3.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Li, Fei; Liu, Xiaolan; Yang, Shengxiang; Yang, Yuzhu; Tetrahedron Letters; (2020);,
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