Reference of 169247-46-5, These common heterocyclic compound, 169247-46-5, name is 1-(Benzyloxy)-4-bromo-2-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 100 mL round bottom flask was charged with EXAMPLE 49B (1.9Og, 5.74 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (1.75g, 6.89 mmol), [l,r-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane (0.234 g, 0.287 mmol), diphenylphosphinoferrocine (0.159g, 0.287 mmol) and potassium acetate (1.689g, 17.21 mmol) in 50 mL dioxane. The mixture was degassed with N2 and heated at 800C overnight, diluted with water, and extracted into ethyl acetate. The organics were washed with brine and dried (MgSO4), filtered, and concentrated. The crude product was purified on silica gel eluting with 0-10percent ethyl acetate/hexane to provide the title compound. MS (DCI(+)) m/e 396 (M+NH4)+; 1H NMR (300 MHz, dimethylsulfoxide- d6) delta ppm 7.64 (dd, 1 H), 7.56-7.16 (m, 7 H), 5.26 (s, 2 H), 1.29 (s, 12 H).
The synthetic route of 169247-46-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; CLARK, Richard, F.; BELL, Randy, L.; BA-MAUNG, Nwe, Y.; ERICKSON, Scott, A.; FIDANZE, Steve, D.; MANTEI, Robert, A.; SHEPPARD, George, S.; SORENSEN, Bryan, K.; WANG, Gary, T.; WANG, Jieyi; WO2010/138576; (2010); A1;,
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