Application of 172282-50-7,Some common heterocyclic compound, 172282-50-7, name is 4-(Difluoromethoxy)benzene-1,2-diamine, molecular formula is C7H8F2N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a mechanical stirrer, Reflux condenser, the thermometer of the four-mouth flask, with lye:Sodium carbonate 6. 6 grams + 20 grams of tap water,Stirring to dissolve, slightly cooling, adding4-difluoromethoxy-o-phenylenediamine 34. 8 g,Stir for 20 min. Heated to 30 C,25-35 C20 g of carbon disulfide was added dropwise,Drop finished 30-40 C insulation condensation 6h,Continue to heat up to 60-70 C insulation 6h, cyclization is complete, add activated carbon decolorization,The filtrate was adjusted to pH 5-6 with sulfuric acid, filtered, washed, dried,5-difluoromethoxy-2-mercapto-1H-benzimidazole was obtained in an amount of 33.2 g,The yield was 95.4% based on 4-difluoromethoxy-o-phenylenediamine.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Difluoromethoxy)benzene-1,2-diamine, its application will become more common.
Reference:
Patent; ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY; JIANGSU YUXIANG CHEMICAL CO., LTD; ZHANG, ZHIGUO; CHENG, YUNTAO; ZHONG, XUHUI; LI, QINGLONG; CHENG, HONGWEI; (6 pag.)CN103539746; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem