Electric Literature of 2338-54-7, A common heterocyclic compound, 2338-54-7, name is 4-Fluoro-3-methylanisole, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-Fluoro-4-methoxy-2-methylbenzene a11 (0.0140 g, 0.10 mmol), acridine photosensitizer (A) (0.0029 g, 0.005 mmol) and L-guanidine were added sequentially under argon atmosphere. Ethyl acetate b1 (0.0218 g, 0.15 mmol), 1,2-dichloroethane (DCE) 2.0 mL.The reaction was irradiated for 48 hours under a 6W blue light at room temperature.After completion of the reaction, the solvent was evaporated under reduced pressure and purified by column chromatography, eluting solvent: (V) petroleum ether / (V) ethyl acetate = 20/1.A yellow liquid (28) (0.0140 g, 83%) was obtained.
The synthetic route of 2338-54-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Central China Normal University; Zhou Shaolin; Shi Weimin; (27 pag.)CN110294685; (2019); A;,
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