Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4457-67-4, name is 1-Bromo-4-methoxybutane, A new synthetic method of this compound is introduced below., Formula: C5H11BrO
EXAMPLE 10 10-Hydroxy-10-(4-methoxybutyl)-2,3,4,10-tetrahydropyrimido[1,2-a]indole Ether (60 ml) and 4-bromo-1-methoxy-butane (10.2 g) were added to magnesium turnings (1.46 g). After formation of the Grignard reagent, the mixture was cooled to 0¡ã and 3,4-dihydropyrimido[1,2-a]indol-10(2H)-one (3.72 g) in dry 1,2-dichloroethane (20 ml) added dropwise over 20 minutes. The solution was stirred under argon at 0¡ã C. for 1 hour, poured onto a swirling mixture of ice (100 ml) and saturated aqueous ammonium chloride (60 ml) and the mixture was stirred for a further 20 minutes. The mixture was concentrated in vacuo and the aqueous residue extracted with chloroform (3*100 ml). The extracts were dried (Na2 SO4) and concentrated in vacuo. Ether (20 ml) was added and the product was filtered and recrystallized from ethyl acetate to give the title compound or the free base (3.55 g), m.p. 128¡ã-139¡ã C. The free base was acidified with ethereal HCl to give the title compound as the hydrochloride, m.p. 178¡ã-179¡ã C. Found: C, 61.55; H, 7.55; N, 8.80percent C16 H22 N2 O2.HCl requires: C, 61.85; H, 7.45; N, 9.0percent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; John Wyeth & Brother Ltd.; US4784996; (1988); A;,
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