Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31963-35-6, name is 1-(2-Phenoxyphenyl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(2-Phenoxyphenyl)methanamine hydrochloride
Example 95: 4-Chloro-6-(2-phenoxy-benzyIamino)-2H-phthalazin-l-one; A mixture 6-bromo-4-chloro-2H-phthalazin-l-one (150 mg, 0.58 mmol), 2- phenoxy-benzylamine hydrochloride (151 mg, 0.64 mmol), Pd2(dba)3 (53 mg, 0.058 mmol), rac-BINAP (132 mg, 0.17 mmol) and NaOt-Bu (200 mg, 2.1 mmol) in DMA (6 mL) was heated at 8O0C for Ih. The mixture was allowed to cool, diluted with EtOAc (25 mL) and washed with water (25 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated. Chromatography on silica (EtOAc/hexanes) yielded the title compound. 4-Chloro-6-(2-phenoxy-benzylamino)-2H-phthalazin-l-one: 81 mg (37.0%): m/z (M+eta)=378. 1H-NMR (DMSO-J5) delta: 12.77 (s,lH), 8.34 (d,lH), 8.03(m,lH), 7.82 (m,3H), 7.71 (m,lH), 7.56 (m,3H), 7.42 (m,2H), 7.33 (dd,lH), 7.20 (s,lH), 4.84 (d,2H).
The synthetic route of 31963-35-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; WO2008/61108; (2008); A2;,
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