In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1187160-18-4, name is 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 7-Methoxy-2,3-dihydro-1H-inden-1-amine hydrochloride
Step A: Rac-7-methoxy-indan-1-ylamine hydrochloride (2.20 g, 0.01 1 mmol) was dissolved in acetic acid (100 mL). After cooling to 0 C. sulfuryl chloride (1.88 mL, 0.23 mmol) was slowly added and the reaction mixture was stirred for 16 h at ambient temperature. Then the solvent was evaporated and the residue was taken up in isopropanol. Thereby a precipitate formed which was isolated and dried on high vacuum to yield rac-4,6-dichloro-7-methoxy-indan-1-ylamine (2.0 g, 68%) as a white solid; MS: m/e=269.6 (M+H+).
The synthetic route of 1187160-18-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kolczewski, Sabine; Riemer, Claus; Roche, Olivier; Steward, Lucinda; Wichmann, Juergen; Woltering, Thomas; US2009/227570; (2009); A1;,
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