Related Products of 4342-43-2,Some common heterocyclic compound, 4342-43-2, name is 2-Methoxycyclohexanamine, molecular formula is C7H15NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 64 To methylene chloride (50 ml) are added 4-(1-methyl-1,2,3,4-tetrazol-5yl)thio-butyric acid (45 mmole) and N-methylmorpholine (50 mmole). To the mixture is added dropwise with stirring methyl chloroformate (50 mmole) with keeping the inner temperature at 10-20 C. by ice-cooling, and thereafter, the mixture is stirred at room temperature for 30 minutes. To the mixture is added 2-methoxycyclohexylamine (54 mmole), and the mixture is stirred at the same temperature for 4 hours. After the reaction, water is added to the reaction mixture. The organic layer is separated and washed with dilute aqueous sodium hydroxide solution, diluted hydrochloric acid and water in order, and dried over sodium sulfate. Inorganic materials are filtered off, and the mother liquor is concentrated. The resulting residue is subjected to column chromatograpy (Wakogel C-200, eluding solvent, benzene_chloroform=4:1, V/V) to isolate N-(4-methoxycyclohexyl)-4-(1-methyl-1,2,3,4-tetrazol-5-yl)thio-butyramide (yield: 43%), colorless liquid, nD11 =1.5263. Elementary analysis for C13 H23 N5 O2 S: Calcd. (%): C,52.50; H,7.79; N,23.55 Found (%): C,52.56; H,7.71; N,23.63
The synthetic route of 4342-43-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Otsuka Pharmaceutical Company, Limited; US4540703; (1985); A;,
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