Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2186-92-7, name is P-anisaldehyde dimethyl acetal, A new synthetic method of this compound is introduced below., Quality Control of P-anisaldehyde dimethyl acetal
Step a); Methyl 4,6-0-(4-methoxybenzylidene)-alpha-D-glucopyranoside(4); A solution of methyl alpha-D-glucopyranoside (10 g, 51.5 mmol) in dimethylformamide (DMF, 50 ml) was added with a catalytic amount of camphorsulfonic acid (CSA) and anysaldehyde dimethylacetal (ADMA, 10 ml, 51.5 mmol) and the mixture was kept under magnetic stirring and low vacuum to remove the methanol formed during the condensation reaction. After 40 min the solvent was evaporated off. The residue was added with a NaHCO3 saturated solution and the resulting diphasic mixture was kept under vigorous stirring for one hour. The resulting precipitate was filtered and washed with an ice-cold bicarbonate solution (100 ml). The residue was triturated in hexane to afford compound 4 as a white solid (15 g, 94%). 4: Rf = 0,31 (EtOAc/MeOH/H2O 7:2:1).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.