Application of 2982-54-9, These common heterocyclic compound, 2982-54-9, name is 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4. Preparation of 3-((2-(4-benzyloxy-phenyl)-ethylamino)-methyl)-7-methyl-chromen-2-one: 7-Methyl-2-oxo-2H-chromen-3-carbaldehyde (380mg, 2.02mmol) (ScetharamaiyerPadmanabhan, Ravikumar Peri and David J. Triggle, Syn. Comm., 26(4), pp 827-831, 1996) and the compound (130mg, 0.40mmol) prepared in the step 3 were dissolved in dried THF (6ml) and methanol (12ml). thereto triethylamine (0.96ml, 6.87mmol) was added and the reaction mixture was stirred at room temperature for 3 hours. Thereafter, the temperature was lowered to O0C, and thereto acetic acid (0.41ml, 7.07mmol) and sodiumborohydride (0.178mg, 2.83mmol) were added, and the reaction mixture was stirred at O0C for 2 hours. Ice water (0.1ml) was added to quench the reaction, and aqueous layer was extracted with ethyl acetate. Combined organic layer was concentrated under reduced pressure. The residue was purified by column chromatography (n-hexane:ethyl acetate = 1:1) to give 240mg (yield: 29.1%, white solid) of the target compound. 1H-NMR (CDC13, 400MHz) delta 6.79-7.79(m, 13H), 5.05(s, 2H), 4.57(m, IH),2.78-3.54(m, 6H), 2.28(s, 3H)
Statistics shows that 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride is playing an increasingly important role. we look forward to future research findings about 2982-54-9.