Electric Literature of 151414-47-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151414-47-0, name is 2,6-Difluoro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows.
Step B: Preparation of 4-(2-Chloro-4-fluorophenyl)-Lambda/-(2,6-difluoro-4-methoxyphenyl)-l,3-dimethyl-lH-pyrazol-5-amine5-Bromo-4-(2-chloro-4-fluorophenyl)-l,3-dimethyl-lH-pyrazole (i.e. the product ofStep A) (0.20 g, 0.66 mmol), palladium(II) acetate (15 mg, 0.066 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (76 mg, 0.13 mmol) and powdered potassium carbonate (1.8 g, 13 mmol) were combined in anhydrous 1,4-dioxane (3 mL), and the mixture was sparged with a subsurface stream of N2 gas for 10 min. 2,6-Difluoro-4-methoxyaniline (0.22 g, 1.3 mmol) was added in one portion, and the reaction mixture was heated at reflux for 22 h. The reaction mixture was filtered through Celite diatomaceous filter aid, and the filter pad was washed with ethyl acetate (20 mL). The filtrate was washed with water (10 mL) and brine (10 mL), dried over MgSOphi and concentrated to leave a semisolid residue. This residue was purified by column chromatography through 5 g of silica gel eluted with a gradient of hexanes/ethyl acetate (20:1 to 1 :3) to give the title compound, a compound of the present invention, as a light-brown solid (48 mg). 1H NMR delta 7.0-7.1 (m, 2H), 6.85 (m, IH), 6.26 (m, 2H), 4.84 (br s, IH), 3.78 (s, 3H), 3.66(s, 3H), 2.08 (s 3H). MS: 382 amu.
The chemical industry reduces the impact on the environment during synthesis 2,6-Difluoro-4-methoxyaniline. I believe this compound will play a more active role in future production and life.