Some common heterocyclic compound, 35896-58-3, name is 1,2,3,4-Tetramethoxy-5-methylbenzene, molecular formula is C11H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 35896-58-3
To a stirred solution of 5a (4.24 g, 20 mmol) in CH2Cl2 (30 mL) was added dichloromethyl methyl ether (6.89 g, 60 mmol) at 0 C followed by addition of TiCl4 (11.38 g, 60 mmol)41 S. Ohkawa, S. Terao, Z. Terashit, Y. Shibouta and K. Nishikawa, J. Med. Chem. 34 (1991), p. 267. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (36)41 (see Scheme 4). The resulting mixture was stirred for 4 h at ambient temperature and then poured into ice water. After stirring vigorously for 10 min, the organic layer was separated. It was washed with water, dried, and evaporated. The residue was chromatographed on silica gel to give 5b (90%) as a light yellow liquid. 1H NMR (500.0 MHz, CDCl3, 298 K): 3.99 (s, 12H, 4× -OCH3), 2.25 (s, 3H, -CH3), 10.45 (s, H, -CHO) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35896-58-3, its application will become more common.