Reference of 89282-70-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89282-70-2 as follows.
To a solution of (2R)-4-(6-(2-fluoro-4-formylphenyl)-1 -oxoisoquinolin-2(1 H)-yl)-2-methyl-2- (methylsulfonyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)butanamide (2.2 g, 4.04 mmol) in 1 ,2- dichloroethane (30 mL) at 0 C was added 2-methoxy-2-methylpropan-1 -amine (1 .250 g, 12.12 mmol). The reaction mixture was stirred at room temperature overnight and sodium triacetoxyhydroborate (2.57 g, 12.12 mmol) was added at 0 C. The reaction was allowed to warm to room temperature and was sirred for 1 hr. The reaction was diluted with DCM (20 ml_) and water (20 ml_) and the aqueous phase was extracted with DCM (20 ml x 3). The combined organic layers were washed with brine (30 ml_), dried over sodium sulphate and concentrated. The residue was purified by silical gel chromatography (MeOH/DCM: 0-20%) to afford (2R)-4-(6-(2-fluoro-4-(((2-methoxy-2- methylpropyl)amino)methyl)phenyl)-1 -oxoisoquinolin-2(1 H)-yl)-2-methyl-2- (methylsulfonyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)butanamide (2.32 g, 3.67 mmol, 91 % yield) as a colorless oil. LCMS: [M+H] 632.4.
According to the analysis of related databases, 89282-70-2, the application of this compound in the production field has become more and more popular.