Some common heterocyclic compound, 109-85-3, name is 2-Methoxyethylamine, molecular formula is C3H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H9NO
[0706] A solution of 6-amino-4-fluoronicotinonitrile (intermediate21, 1.10 g, 8.02 mmol) in DMA (20 ml) wastreated with 2-methoxyethylamine (2.07 ml, 24.1 mmol) andDIPEA ( 4.20 mL, 24.1 mmol), heated to 50 C. and stirred for15 h. The reaction mixture was cooled to room temperatureand concentrated. The crude material was purified by normalphase chromatography (24 g silica gel cartridge, heptanes/EtOAc 100:0 to 0: 100). The product containing fractionswere concentrated and dried under vacuum to give the titlecompound as an off-white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109-85-3, its application will become more common.