Application of 2050-46-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2050-46-6 name is 1,2-Diethoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
18.9 g of 1,2-diethoxybenzene obtained in Production Example 9 and 22.0 g of 3-bromobenzoyl chloride were dissolved in 100 ml dichloromethane, and 100 ml of 1.0 M tin tetrachloride in dichloromethane was added dropwise thereto under ice-cooling. After the dropwise addition, the mixture was further stirred at room temperature for 15 hours. The reaction solution was poured into ice-cold water to terminate the reaction, and the organic layer was recovered, washed with water twice and with brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the crude product was recrystallized from hexane-ethyl acetate to give 23.8 g of the title compound as colorless crystals. 1H-NMR (400 MHz, CDCl3) delta 1.46-1.52 (6H, m), 4.13-4.21 (4H, m), 6.89 (1H, d, J=8.8 Hz), 7.32 (1H, dd, J=8.8,2.0 Hz), 7.35 (1H, t, J=7.8 Hz), 7.46 (1H, d, J=2.0 Hz), 7.64-7.71 (2H, m), 7.88 (1H, t, J=l.6 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Diethoxybenzene, and friends who are interested can also refer to it.