Electric Literature of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.
A solution of 2- [1- (2- {4- [1- (4,4-dimethyl-4,5-211-oxazol-2-yl) -1-methyl-ethyl] } -piperidin-4-yl] -1H-benzimidazole was dissolved in 60 mL of THF, and 620 mg of sodium methoxide was added in portions to produce a large amount of air bubbles. The solution was clouded by clarification, After 2 h of reaction, the mixture was heated to 70 C, 2032 muL 2-bromoethyl ether was added, Reaction 2 h, TLC monitoring reaction, After stopping the reaction, add a small amount of water to quench the reaction, concentrate out of THF, add methylene chloride and wash with saturated NaCl solution three times, the organic layer was concentrated with the appropriate amount of dichloromethane to dissolve it, adding n-hexane beating to obtain light yellow solid, Filtration and drying gave solid 2. 0 g, yield 90%
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.