Electric Literature of 59557-91-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59557-91-4, name is 4-Bromo-2-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Embodiment 8A 4-Bromo-2-methoxy-5-nitroaniline 2-Methoxy-4-bromoaniline (5.00g, 24.75mmol) was added to concentrated H2SO4 (50mL) at 0 to 5C and then guanidine nitrate (3.02g, 24.75mmol) was added in batches. The mixture was stirred at 0 to 5C for 30 minutes. TLC showed the reaction was complete and the reaction mixture was slowly added dropwise to a solution of NaHCO3 (100g) in water (1L), the temperature was controlled below 15C. The resulting mixture was filtered to deliver the title compound (yellow solid, 5.40g, yield 83.90%). 1H NMR (400MHz, CDCl3): delta, 7.39 (s, 1H), 7.01 (s, 1H), 4.09 (br. s., 2H), 3.96 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-methoxyaniline, other downstream synthetic routes, hurry up and to see.