Reference of 910251-11-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 910251-11-5 name is Potassium trifluoro(methoxymethyl)borate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A vessel was charged with 4-[[2-(3-bromophenyl)acetyljaminoj-N-tert-butyl-pyridine-2- carboxamide (Example 54 step 1)(50 mg, 0.13 mmol) PdCl2dppf (3 mg), potassium trifluoro(methoxymethyl)boranuide (0.45 mL, 0.26 mmol) 2M aq. sodium carbonate (0.26mL, 0.51 mmol) and heated at8O Cfor 16 hours. The mixture was allowed to cool to room temperature, poured onto water (20 mL) and extracted into EtOAc (3 x 20 mL). The combined organic extracts were washed with brine (50 mL), dried over Na2504 and concentrated in vacuo. The residue was dissolved in DMSO:MeCN (800 p1, 1:1), filtered and purified by preparative HPLC (acidic pH, early elution method) to afford the titledcompound as an off-white solid.1H NMR (500 MHz, DMSO-d6) O 10.76 (5, 1H), 8.44 (d, J = 5.5 Hz, 1H), 8.18 (d, J = 2.1Hz, 1H), 8.02 (5, 1H), 7.81 (dd, J = 5.5, 2.2 Hz, 1H), 7.34-7.27 (m, 2H), 7.25 (d, J = 7.7Hz, 1H), 7.20 (d, J = 7.5 Hz, 1H), 4.40 (5, 2H), 3.71 (5, 2H), 3.29 (5, 3H), 1.39 (5, 9H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Potassium trifluoro(methoxymethyl)borate, and friends who are interested can also refer to it.