Electric Literature of 20781-20-8,Some common heterocyclic compound, 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2,4- dimethoxybenzaldehyde (Sigma-Aldrich, 5.00 g, 30.1 mmol) in MeOH (100 mL) was added 2,4-dimethoxybenzylamine (Sigma-Aldrich, 5.53 mL, 33.1 mmol). The resulting mixture was stirred at RT for 1 h and then sodium borohydride (1.30 g, 34.3 mmol) was added slowly. Gas evolution was observed. After stirring at RT overnight, the reaction was quenched with water and then partially concentrated to remove MeOH in vacuo. The residue was extracted with EtOAc (3X). The combined organic layers were washed with brine (1X), dried over anhydrous magnesium sulfate and concentrated in vacuo to afford 98.1 as a colorless oil. The product was used directly in the next step. LCMS-ESI (pos.) m/z: 318.2 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2,4-Dimethoxyphenyl)methanamine, its application will become more common.