Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7664-66-6, name is 4-Isopropoxyaniline, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks
[Example 1] Preparation of 1-(4-chlorobenzyl)-3-ethylamino-6-(4-isopropoxyphenylamino)benzene (I-071) To a mixture of 3-bromo-4-fluoro-1-nitrobenzene (1.0 g, 4.6 mmol) and DMSO (5 mL) were added potassium carbonate (1.01 mg, 7.3 mmol) and 4-isopropoxyaniline (1.03 g, 6.8 mmol), and the resulting mixture was stirred at 100C for 0.5 hours. To the reaction mixture was added water (20 mL), and the resulting mixture was extracted with ethyl acetate (30 mL*2). The extract was washed by brine (20 mL) and water, and the organic layer was dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane). The resulting residue was precipitated by ethyl acetate and hexane to give 3-bromo-4-(4-isopropoxyphenylamino)-1-nitrobenzene (0.55 g, Yield: 35%)as orange solid. 1H-NMR (delta ppm TMS/DMSO-d6): 1.28 (6H, d, J = 6.0 Hz), 4.61 (1H, sept, J= 6.0 Hz), 6.76 (1H, d, J = 9.0 Hz), 6.97 (2H, d, J = 9.0 Hz), 7.19 (2H, d, J = 9.0 Hz), 8.00 (1H, dd, J = 8.9 Hz, 2.4 Hz), 8.34 (2H, d, J = 2.4 Hz).
The synthetic route of 7664-66-6 has been constantly updated, and we look forward to future research findings.