Related Products of 82830-49-7, The chemical industry reduces the impact on the environment during synthesis 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene, I believe this compound will play a more active role in future production and life.
To a solution of 2-fluoro-1,4-dimethoxybenzene (2.56 g, 0.0 16 mol) in dry THF (100 mL) at -78 C was added n-BuLi (2.5 M, 7 mL, 0.0 17 mol) dropwise under a N2 atmosphere. The reaction was stuffed at -78 C for 1 h and then ethyl chloroformate (1.8 g, 0.0 17 mol) inTHF (50 mL) was added dropwise at -78 C. The reaction mixture was stirred at -78 C for another 1 h. The reaction was warmed slowly to room temperature and quenched with a saturated aqueous NH4C1 solution (100 mL). The reaction mixture was extracted with ethyl acetate (100 mL x 3). The combined organic phases were dried with MgSO4 and concentrated to afford the crude material which was purified by column chromatography on silica gel(petroleum ether/ethyl acetate 1:10 to 1:5) to afford pure methyl 2-fluoro-3,6- dimethoxybenzoate (2.28 g, 65% yield).
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