Electric Literature of 4393-09-3,Some common heterocyclic compound, 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
8-Chloro-2,2-dimethyl-5-(pyrrolidin-1 -yl)-1 ,4-dihydro-2/-/- pyrano[4″,3″:4l,5′]pyrido[3′,2′:4,5]thieno[3,2-c/]pyrimidine (O.Odeltag, 0.21 mmol, see Preparation 24) is suspended in ethanol (5 ml) and (2,3-dimethoxybenzyl)amine (0.16 ml, 1.07 mmol) is added. The mixture is refluxed for 24h and then allowed to cool to room temperature. The solvent is evaporated under vacuum and the residue is purified by chromatography, eluting first with CH2CI2 and then with CH2CI2:Me0H 99:1. 85 mg of the desired final product are obtained. Yield= 79%. m.p. 166.0-167.50C1 H NMR (300 MHz, DMSO-D6) delta ppm 1.32 (s,6 H) 1.88 (m, 4 H) 3.33 (d, J=7.02 Hz, 3 H) 3.60 (m, 4 H) 3.78 (m, 6 H) 4.74 (d, J=5.80 Hz, 2 H) 4.83 (s, 2 H) 6.83 (dd, J=7.17, 1.98 Hz, 1 H) 6.96 (m, 1 H) 8.01 (t, J=5.80 Hz, 1 H) 8.48 (s, 1 H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2,3-Dimethoxyphenyl)methanamine, its application will become more common.