Related Products of 111-95-5,Some common heterocyclic compound, 111-95-5, name is Bis(2-methoxyethyl)amine, molecular formula is C6H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The following reactions were carried out in an argon gas atmosphere. There was dissolved, in toluene (3 mL), 2-(4-bromo-phenyl)-5-chloro-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine (59.0 mg, 0.150 mM), there were then added, to the solution, a solution of sodium t-butoxide (21.6 mg, 0.225 mM), tris(dibenzylidene acetone) di-palladium (6.9 mg, 0.0076 mM) and tri-t-butyl phosphine (10.9 muL, 0.0453 mM) in toluene (0.556 mL) and bis-(2-methoxyethyl)-amine (33.2 muL, 0.225 mM) and the resulting mixture was stirred at 80 C. for 4 hours and a half. This reaction liquid was diluted with a saturated aqueous common salt solution and then extracted with ethyl acetate. The extracts thus obtained were combined, dried over anhydrous sodium sulfate, then the solvent was distilled off and the resulting residue was purified by the silica gel column chromatography (ethyl acetate//hexane=1:4 to 2:3) to thus give the title compound (42.0 mg, yield: 63%). 1H-NMR (300 MHz, CDCl3): delta 3.37 (2s each 3H), 3.55-3.64 (m, 8H), 3.83-3.86 (m, 4H), 3.97-4.00 (m, 4H), 6.10 (s, 1H), 6.65 (s, 1H), 6.78 (d, 2H, J=8.5 Hz), 7.79 (d, 2H, J=8.5 Hz); MS (ESI) m/z 446 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Bis(2-methoxyethyl)amine, its application will become more common.