Month: April 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene

l-(4-Difluoromethoxy-3-methyl-phenyl)-cis-3,5-dimethyl-piperazine:; To 4-bromo-l- (difluoromethoxy)-2-methylbenzene (2.36 g, 10.00 mmol) in toluene (50 mL) was added cis-2,6- dimethylpiperazine (5 g, 58.14 mmol), Pd(OAc)2 (120 mg, 0.53 mmol), BINAP (380 mg, 0.61 mmol), and t-BuOK (2.2 g, 19.64 mmol). The resulting solution was stirred for 4 hours at 80C. The solution was cooled to room temperature and washed with H2O (2 X 50 mL), dried over Na2SCt, concentrated, and purified by silica gel column chromatography (10:1 CH2CWMeOH) to give 1.1 g (41%) of l-(4- (difluoromethoxy)-3-methylphenyl)-3,5-dimethylpiperazine.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 888327-32-0.

Reference of 349-55-3, The chemical industry reduces the impact on the environment during synthesis 349-55-3, name is 3-Methoxy-5-(trifluoromethyl)aniline, I believe this compound will play a more active role in future production and life.

3-methoxy-5- (trifluoromethyl)aniline (100 mg, 0.52 mmol) was dissolved in CHC13 (5.2 mL) and t-butyl nitrite (124 muL, 1.05 mmol) was added dropwise by syringe. Iodine (266 mg, 1.05 mmol) was added and then the reaction was slowly heated to 50C and was maintained at this temperature for an hour and thirty minutes. The reaction was then cooled to room temperature and poured into aq. NaHS03 (50 mL). The mixture was extracted with EtOAc (50 mL) and the organic extracts were washed with aq. NaHS03 (3 X 50 mL) and brine (20 mL), dried over Na2S04, filtered, and concentrated. Purification by flash chromatography with 1% to 15% EtOAc/hexanes afforded 1-iodo-3-methoxy-5-(trifluoromethyl)benzene. Rf= 0.75 (25% EtOAc/hexanes). ‘H NMR (CDC13, 500 MHz) 8 7.53 (s, 1H), 7.41 (s, 1H), 7.09 (s, 1H), 3.82 (s, 3H). Step B: 3-Methoxy-5-(trifluoromethyl)benzonitrile To a solution of 1-iodo-3-methoxy-5-(trifluoromethyl)benzene (200 mg, 0.66 mmol) in DMF (2 mL) was added CuCN (300 mg, 5.0 mmol). The reaction was stirred at 100C for 24 hours and then poured into aq. NH3 (40 mL). The mixture was extracted with EtOAc (70 mL) and the organic extracts were washed with brine (25 mL), dried over Na2S04, filtered, and concentrated. Purification by flash chromatography with 5% to 80% EtOAc/hexanes afforded 3-methoxy-5- (trifluoromethyl)benzonitrile. 0.64 (50% EtOAc/hexanes). ‘H NMR (CDC13, 600 MHz) 8 7.47 (s, 1H), 7.34 (s, 1H), 7.31 (s, 1H), 3.89 (s, 3H). Step C: 3-Methoxy-5-(trifluoromethyl)benzaldehyde A mixture of 3-methoxy-5- (trifluoromethyl)benzonitrile mg, 0.43 mmol) and Pt02 (9.8 mg, 0.043 mmol) in 88% formic acid (651 muL) was heated to 60C. The reaction was stirred at this temperature for thirty minutes. The reaction was then cooled to room temperature, diluted with hexanes (5 mL), loaded on a silica gel column, and purified with 1% to 15% EtOAc/hexanes to afford 3-methoxy-5- (trifluoromethyl) benzaldehyde. Rf= 0.56 (25% EtOAc/hexanes). ‘H NMR (CDCl3,500 MHz) 8 10.01 (s, 1H), 7.71 (s, 1H), 7.56 (s, 1H), 7.39 (s, 1H), 3.92 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-5-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1836-62-0,Some common heterocyclic compound, 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Compound 5a (100 mg, 0.42 mmol), and 2-(2-methoxyphenoxy)ethanamine (84 mg, 0.50 mmol) were added to ethanol and theresulting heterogeneous solution was reuxed for 24 h. Themixture was cooled to room temperature and ltered through a padof celite and the ltrate was concentrated under reduced pressure.The residue was puried by ash chromatography on silica-gelwith 10% methanol in ethyl acetate. Yielding 83% compound 9a(176 mg) as a white solid. Compound 9b was synthesized followingthe procedure of preparation 9a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Methoxyphenoxy)ethylamine, its application will become more common.

Some common heterocyclic compound, 22483-09-6, name is 2,2-Dimethoxyethanamine, molecular formula is C4H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H11NO2

General procedure: A solution of amino acetaldehyde dimethyl acetal 2a (10. 514 g, 1.081 mL, 10 mmol), purchased from Alfa Aesa, and an aldehyde (10 mmol) in dry ethanol was placed in a round bottom flask and stirred for 12 h. To that solution, sodium borohydride powder (0.567 g, 15 mmol) was added at 0 C slowly over 5 minutes. the solution was then warmed to room temperature. After stirring for 4 h, the reaction was quenched with 3 drops of water and the mixture was filtered through a pad of celite. The solvent was evaporated under reduced pressure, the residue was extracted with 100 mL of ethyl ether and washed with100 mL of water. The organic layer was dried over MgSO4 anhydrous. Ethyl ether was then evaporated and the resulted viscous liquid was purified by flash column chromatography (SiO2; 4:1 then 3:1 and finally 1:1hexanes/ethyl acetate).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 22483-09-6, its application will become more common.

Reference of 38336-04-8,Some common heterocyclic compound, 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 2-(4-chloro-3-nitrophenyl)-2-methylpropanoate (3a)(16.15 g, 0.0594 mol), 4 (27.77 g, 0.149 mol), K2CO3 (28.69 g,0.208 mol), KI (0.99 g, 5.94 mmol), TBAB (1.91 g, 5.94 mmol) and150 mL DMSO were added into a round-bottomed flask. The mixturewas heated to 120 C for 24 h then cooling to room temperature.The reaction mixture was diluted with saturated NH4Claqueous solution (250 mL) and extracted with CH2Cl2 (450 mL).The combined organic layer was washed with brine (300 mL), driedover anhydrous sodium sulfate, filtered, and concentrated in vacuo.The residue was purified by silica gel column chromatography (PE:EtOAc = 4:1) to give compound 5a (15.82 g) as yellow oil in 69%yields. 1H NMR (300 MHz, CDCl3) d (ppm) 8.27 (s, 1H), 8.19 (d,J = 2.4 Hz, 1H), 7.41-7.30 (m, 5H), 6.84 (d, J = 9.0 Hz, 1H), 4.61 (s,2H), 4.13 (q, J = 7.1 Hz, 2H), 3.77 (t, J = 5.4 Hz, 2H), 3.53 (q,J = 5.3 Hz, 2H), 1.58 (s, 5H), 1.21 (t, J = 7.1 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Benzyloxy)-1-ethanamine, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 944317-92-4, name is 1-Bromo-4-fluoro-5-isopropyl-2-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944317-92-4, SDS of cas: 944317-92-4

lOg (0.0405 mol) product 4, 11.05g(0.04455 mol) 2-methoxycarbonyl-4- trifiuromethylphenylboronic acid, 2.45g tetra-(triphenylphosphine) palladium, 16g anhydrous potassium carbonate and 100 ml tetrahydrofuran were added into a 250 mL 3-neck fiaskto form a suspension. The mixture was heated to reflux overnight, then cooled to room temperature, filtered, poured into 300 mL water, and was extracted by 3><300 mL ethyl acetate. The organic phase was washed by saturated NaCl solution, dried by anhydrous Na2S04 and distilled under vacuum to obtain a yellow solid. Recrystallization in ethyl acetate gave 7.82g of product 5. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 120-11-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120-11-6, name is 1-(Benzyloxy)-2-methoxy-4-(prop-1-en-1-yl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The mixture of the substrate (0.250 mmol), 0.5% Pd/MS3A or 0.5% Pd/MS5A (10 wt % of the substrate) and MeOH (1 mL) was stirred under H2 atmosphere (balloon) at room temperature. After a given period, the reaction mixture was filtered through a membrane filter (Millipore, Millex-LH, 0.45 mm), and the filtrate was concentrated in vacuo to produce the corresponding reduced product.

The synthetic route of 1-(Benzyloxy)-2-methoxy-4-(prop-1-en-1-yl)benzene has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 7252-83-7

As described by Doel et al.,13 a solution of adenine or thymine (1 equiv) and K2CO3 (1 equiv) in DMF (10 mL) was stirred at 100 C in the presence of 2-bromo-1,1-dimethoxyethane (1.1 equiv). After 24 h, the reaction was filtered and the solvent removed under reduced pressure. The crude mixture was purified by column chromatography in silica gel with MeOH: CH2Cl2 or EtOAc: hexane as mobile phase. Corresponding 9-(2,2-dimethoxyethyl)-adenine and 1-(2,2-dimethoxyethyl)-thymine were obtained in 61% and 38% isolated yields respectively. Both acetals were completely hydrolyzed after 1 h stirring in HCl 1 N at 90 C, to yield the corresponding aldehydes.20

The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.

Related Products of 204452-91-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 204452-91-5 name is 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The compound (12 g, 57.6 mmol) prepared in the above step 2 was dissolved in acetonitrile (192 ml), and N-bromosuccinimide (NBS) (10.77 g, 60.5 mmol) was slowly added at room temperature. After the reaction mixture was stirred at room temperature for 30 minutes, And concentrated under reduced pressure. After extracting the reaction residue obtained from the above with diethyl ether and ice water, The organic layer was washed with brine, dried over sodium sulfate, concentrated under reduced pressure, and purified by MPLC to obtain yellow To give the desired compound (11 g, 66%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine, and friends who are interested can also refer to it.

Some common heterocyclic compound, 456-49-5, name is 1-Fluoro-3-methoxybenzene, molecular formula is C7H7FO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7FO

The 3-fluoro anisole (15 g, 119 mmol) was placed in THF (300 mL) and cooled to about -78 C., and then n-BuLi (89 mL 1.6 M in hexanes) was added while maintaining the temperature at around -70 C. The mixture was stirred for about 15 minutes, and bromine (18.9 g, 119 mmol) was added over 10 minutes. The mixture was warmed to r.t. and stirred overnight. The mixture was quenched with water, diluted with ether (500 mL) and partitioned between water/ether (1/1 300 mL). The water layer was back extracted with ether (250 mL), and the combined organic fractions were dried, filtered and concentrated. The dark residue was distilled under house vacuum (product 115-130 C.) to recover about 13.8 g of the product as a gray oil (57%/).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 456-49-5, its application will become more common.