Month: April 2021

Some common heterocyclic compound, 1535-75-7, name is 2-(Trifluoromethoxy)aniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(Trifluoromethoxy)aniline

General procedure: Under nitrogen atmosphere, dry CH2Cl2 (30 mL), amine (0.02 mol), and Et3N (0.05 mol) wereadded to a three-necked round bottom ask and stirred for 0.5 h, then chloroacetyl chloride droppedslowly and reacted for 3 h at room temperature. Then, the solution was washed with 2 mol L1hydrochloric acid (30 mL), saturated aq NaHCO3 solution (30 mL), and brine (40 mL), successively,then dried over anhydrous Na2SO4 and filtered. After evaporating CH2Cl2 in vacuum, the obtainedcrude product was rened by recrystallization using ethyl acetate/petroleum ether.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1535-75-7, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 645-36-3, name is 2,2-Diethoxyethanamine, A new synthetic method of this compound is introduced below., Formula: C6H15NO2

Dissolve N- (2-chloropyrimidine-4-substituted) -4-fluorobenzamide (5g, 19.9mmol) in toluene (50mL), cool to 0 C, and slowly drop in dichlorosulfoxide under nitrogen protection (7.1 g, 59.8 mmol), transferred to room temperature for 1 hour, and then refluxed overnight. TLC monitoring, after the reaction was completed, the solvent and dichlorosulfoxide were removed to obtain (Z) -N- (2-chloropyrimidine-4-substituted) -4-fluorobenzimidyl chloride.Dissolve aminoacetaldehyde diethanol (3.5 g, 23.9 mmol) and TEA (4.0 g, 39.8 mmol) in dichloromethane (100 mL), cool to 0 C, and obtain (Z) -N- (2-Chloropyrimidine-4-substituted) -4-fluorobenzimidyl chloride was dissolved in dichloromethane (100 mL), and the solution was slowly added dropwise. The mixture was naturally warmed to room temperature and stirred overnight. Monitored by TLC. After the reaction was completed, the mixture was washed with a saturated ammonium chloride aqueous solution and a saturated saline solution, dried over anhydrous Na2SO4, filtered, and dried. Purification by silica gel column chromatography gave a yellow solid (7 g, 95.7%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 645-36-3

4-(2-bromoethyl)heptane (4.14 g, 1.0 eq, 20 mmol) was dissolved in 30 mL of DMF and the amino acetal was added(2.66 g, 1.0 eq, 20 mmol) and K2CO3 (5.5 g, 2.0 eq, 40 mmol).After the reaction solution was reacted at 100 C. for 6 hours, the reaction was completed by TLC (PE:EA=1:1).The reaction solution was poured into water (50 mL) and extracted with ethyl acetate (50 mL x 3).The combined reaction solution was washed successively with saturated aqueous NH 4 Cl (50 mL×3), water (30 mL) and saturated brine (30 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to give the product as a yellow oil (4.2 g, Y=81.1%). .

The synthetic route of 2,2-Diethoxyethanamine has been constantly updated, and we look forward to future research findings.

41406-00-2, name is 3-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H13NO

EXAMPLE 1 Synthesis of o-trifluoromethyl-m’-isopropoxybenzoic anilide. To a tetrahydrofuran solution containing 1.5 g (0.01 mole) of m-isopropoxyaniline and 1.2 g (0.011 mole) of triethylamine, while being cooled in ice water, was added slowly 2.3 g (0.011 mole) of o-trifluoromethylbenzoyl chloride. After having been stirred for 2 hours at room temperature, the reaction mixture was freed from triethylamine hydrochloride by filtration and then from the solvent by distillation under reduced pressure. The residue was recrystallized from n-hexane to obtain 2.9 g (91% yield) of the intended product melting at 95 to 97 C.

The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.

Related Products of 19056-40-7, These common heterocyclic compound, 19056-40-7, name is 4-Bromo-3-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the solution of 4-bromo-3-methoxyaniline (17.4 g, 86.6 mmol) in dichloromethane (117 mL) cooled to 0 °C was added diisopropylethylamine (22.4 g, 173.2 mmol) and the mixture was stirred for 10 mm. To this mixture methylchloroformate (9.8 g, 103.9 mmol) was added dropwise. The reaction mixture was warmed gradually to room temperature and stirring continued for 2 h. Upon completion of the reaction, it was quenched with ice cold water (100 mL) and diluted with ethyl acetate (200 mL). The organic layer was washed with brine solution (100 mL), dried over sodium sulfate and concentrated under reduced pressure to affordmethyl (4-bromo-3-methoxyphenyl)carbamate (13 g, 58percent yield) as light yellow solid. LCMS (ESI) m/e 258.0 [(M), calcd for C9H9BrNO3, 258.0]; LC/MS retention time (method A): tp. = 1.68 min.

Statistics shows that 4-Bromo-3-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 19056-40-7.

Adding a certain compound to certain chemical reactions, such as: 79128-08-8, name is 1,3-Diisopropoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 79128-08-8, Formula: C12H18O2

General procedure: A solution of 1,3-dialkoxybenzene (5.2 mmol) in dry THF(31 mL) was cooled to 0 C and treated with a 1.66 M solution of butyllithium in hexane (6.2 mmol). The mixture was left under magnetic stirring at room temperature for 2 h, added with dry DMF (1.0 mL, 12.9 mmol), left under stirring for additional 2 h and finally hydrolyzed with 0.5 M HCl (50 mL). The two phases were stirred for 30 min then separated. The aqueous phase was extracted with Et2O (3 20 mL) and the extracts were combined with the organic phase and dried (Na2SO4). After removal of the solvent at reduced pressure the crude benzaldehydes were obtained and purified as described below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Diisopropoxybenzene, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 5414-19-7,Some common heterocyclic compound, 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane, molecular formula is C4H8Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrileA solution of 2-(4-phenylthiazol-2-yl)acetonitrile (0.84 g, 4.19 mmol) in THF (25 ml.) was cooled to 0 C. NaH was added (0.5 g, 60% dispersion in oil) portionwise over 10 min. The resulting mixture was allowed to warm up to room temperature and stirred for 20 min. 2-Bromoethyl ether (1.58 ml_, 12.5 mmol) was added dropwise. The reaction mixture was further stirred at room temperature for 1 h and then quenched with saturated NH4CI solution. The reaction mixture was diluted with EtOAc and the organic layer was washed with H20 and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel 60-120 mesh, eluent 4-8% EtOAc in petroleum ether) to afford 4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrile (0.97 g, yield 85%) as a yellow solid: 1 H NMR (300 MHz, CDCI3) delta 7.91 -7.94 (m, 2H), 7.51 (s, 1 H), 7.37-7.48 (m, 3H), 4.07-4.14 (m, 2H), 3.87-3.96 (m, 2H), 2.32-2.43 (m, 4H). MS (ESI) m/z: Calculated for C15H14N2OS: 270.08; found: 271 .2 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-(2-bromoethoxy)ethane, its application will become more common.

Related Products of 1535-75-7, These common heterocyclic compound, 1535-75-7, name is 2-(Trifluoromethoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Acetamides (1a-1x, 1ab, 1ac and 1ba-1bc). To a solution of 2-phenylacetic acid (7.0mmol), 2-(trifluoromethoxy)aniline (7.7mmol) in anhydrous CH2Cl2 (25mL) were added EDCI (1.745g, 9.1mmol) and DMAP (256.6mg, 2.1mmol). The reaction mixture was stirred at room temperature overnight, diluted with HCl (1M) aqueous solution, and extracted with CH2Cl2 (3×25mL). The combined organic phase was washed with saturated NaHCO3 aqueous solution and brine, dried over anhydrous Na2SO4, and concentrated under vacuum. Purification by flash chromatography (Silica gel, petroleum ether: ethyl acetate=50: 1 as eluent) gave the corresponding 2-phenyl-N-[2-(trifluoromethoxy)phenyl]acetamide compound.

The synthetic route of 1535-75-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29578-39-0, name is 1-Bromo-3-fluoro-5-methoxybenzene, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

To a solution of 1-bromo-3-fluoro-5-methoxybenzene (15 g,73.16 rnmol), tris(2-methylphenyl)phosphane (1.781 g, 5.85rnmol) and ethyl acrylate (11.90 mL, 109.74 mmcl) in TEA (135 mL) was added palladium(II) acetate (0.329 g, 1.46 nimnol) at room temperature under nitrogen atmosphere, and the mixturewas stirred at 90C for 2 days. The solvent was evaporated under reduced pressure, the residue was diluted with water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried overmagnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give ethyl (E)-3-(3-fluoro-5- methoxyphenyl)acrylate (14.2 g, 63.3 mmcl, 87%) as a colorless oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27060-75-9, name is 1-Bromo-4-methoxy-2-methylbenzene, A new synthetic method of this compound is introduced below., Product Details of 27060-75-9

a 4-Bromo-3-bromomethylanisole To a stirred solution of 4-bromo-3-methylanisole (100 g, 497 mmol) in dry dichloromethane (500 mL) was added N-bromosuccinimide (97 g, 545 mmol) followed by benzoyl peroxide (6 g, 25 mmol). The reaction was gently refluxed with a 150 watt flood lamp with reflector placed approximately 12 inches from the reaction flask. After 24 h the reaction was concentrated by rotary evaporation to half its volume and allowed to sit for 4 h. The white precipitate which formed was filtered off and rinsed with a small volume of dichloromethane. The filtrate was concentrated to dryness and the remaining solid was triturated with hexanes and filtered. Drying under vacuum gave the title compound (100.25 g, 72%) as white needles: GC tR=6.56 min (HP 530 mum*20 m methylsilicone column, He carrier flow 20 mL/min, 100 C. initial temp., 1 min initial time, 10 C./min rate, 200 C. final temp., 1 min final time); 1H NMR (400 MHz, CDCl3) delta 7.44 (d, J=10 Hz, 1H), 6.99 (d, J=3 Hz, 1H), 6.73 (dd, 1H), 4.55 (s, 2H), 3.80 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.