Month: April 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Bromo-1,1-dimethoxyethane

To an aqueous (10 kg) solution of 3,5-dibromopyrazine-2-amine (1018 g, 4.03 mol), 2-bromo-1,1-dimethoxyethane (1.79 kg, 4.14 mol) was added at room temperature and stirred for 2 hours while heating under reflux. To the reaction solution, water (15.3 kg) and sodium hydrogen carbonate (744 g) were added and further stirred for 15 minutes. The resultant solid substance was obtained by filtration to obtain the titled compound (1106 g, 3.99 mmol, 99%) as a brown solid substance.1H-NMR (400 MHz, DMSO-d6) delta 7.90 (s, 1H), 8.23 (s, 1H), 9.02 (s, 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7252-83-7.

Electric Literature of 22236-10-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22236-10-8, name is 4-(Difluoromethoxy)aniline, This compound has unique chemical properties. The synthetic route is as follows.

In a 20 mL four-necked flask, 4-(difluoromethoxy)aniline (0.5 g, 3.14 mmol) and hydrochloric acid (37% in water, 0.54 ml, 6.6 mmol) were combined with water (5 ml) to give a light yellow solution. Cooled to 0 C using an ice-bath, sodium nitrite (217 mg, 3.14 mmol) was dissolved in water (1 ml) and added carefully ensuring that the temperature did not increase above 5 C. Sodium azide (204 mg, 3.14 mmol) was dissolved in water (1 ml) and added drop-wise to the orange solution, keeping the temperature below 5 C. The reaction mixture was cooled at 0-5 C for 1 hour and an orange emulsion was observed. The layers were separated using TBME and the organic layer was washed with brine, dried over sodium sulphate and filtered. The filtrate was concentrated under vacuum to yield l-azido-4-(difluoromethoxy)benzene as an orange liquid. In a 50 ml round-bottomed flask, l-azido-4-(difluoromethoxy)benzene (540 mg, 2.92 mmol) was combined with THF (10 ml) and dimethylsulfoxide (0.16 ml) to give an orange solution. Then ethyl propiolate (858 mg, 0.89 ml, 8.75 mmol), copper (I) iodide (556 mg, 2.92 mmol) and 2,6- lutidine (625 mg, 0.68 ml, 5.83 mmol) were added and the reaction mixture was stirred for 2 hours at room temperature. Water and ethyl acetate were added and the layers were separated. The organic layer was washed with 1 N hydrochloric acid and brine, dried over MgS04 and filtered. The filtrate was concentrated under vacuum to yield a brown solid, which was adsorbed on silica gel and purified by flash chromatography (20 g Silica gel, 20% ethyl acetate in heptane) yielding 698 mg (84%) of a light yellow solid. MS (ISP): 284.2 ([M+H]+).

The chemical industry reduces the impact on the environment during synthesis 4-(Difluoromethoxy)aniline. I believe this compound will play a more active role in future production and life.

Synthetic Route of 10541-78-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10541-78-3, name is 2-Methoxy-N-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 2-methoxyl-N-methylaniline (27.7 mg, 0.2 mmol) and Et3AI (196 mul_, 1.9 M in toluene, 0.2 mmol) in 1 ,2-dichloroethane (1 mL) which was preheated at 50 0C for 10 min under N2 atomsphere, was added 4-chloro-5-(4-cyano-6- trifluoromethyl-pyridin-3-yl)-2-methoxy-benzoic acid methyl ester (50 mg, 0.14 mmol ). The mixture was sealed in N2 atomsphere and heated at 80 0C for 16 hrs. Upon cooling to rt, the mixture was quenched with 2 N HCI (5 mL) and diluted with 1 ,2- dichloroethane. The organic layer was separated and concentrated. The residue was purfied via reverse phase preparative LCMS to yield 4-chloro-5-(4-cyano-6- trifluoromethyl-pyridin-3-yl)-2-methoxy-N-(2-methoxy-phenyl)-N-methyl-benzamide 38- 1 (4.9 mg). MS [M+H]+ 475.9; tR = 5.91 min (method 3)

The chemical industry reduces the impact on the environment during synthesis 2-Methoxy-N-methylaniline. I believe this compound will play a more active role in future production and life.

Reference of 1462-37-9, These common heterocyclic compound, 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: alpha-Monosubstituted malonic diester 1 was synthesized according to the reported procedure as follows.3 tert-Butyl methyl malonate was purchased from Kanto Chemical, and used without further purification. The physical properties and spectral data of the new compounds, 2-(2-methylbenzyl)malonate 1g, 2-prenylmalonate 1l, and 2-(2-benzyloxyethyl)malonate 1o, are listed below. A 100 mL round-bottom flask equipped with a stirring bar was charged with tert-butyl methyl malonate (846 muL, 5.0 mmol) and DMF (10 mL). To the solution, sodium hydride (60percent oil suspension, 200 mg, 5.0 mmol) was added. The reaction was allowed to stir at 0 °C for 30 min. To the mixture, corresponding alkyl halide (5.0 mmol) was added at 0 °C and the mixture was stirred at room temperature for 24 h. To the reaction mixture, H2O was added, and the mixture was extracted with CH2Cl2 (3 * 20 mL), dried over MgSO4, and concentrated in vacuo. The remaining residue was purified by silica gel column chromatography (hexane/ethyl acetate) to afford the desired product 1.

Statistics shows that ((2-Bromoethoxy)methyl)benzene is playing an increasingly important role. we look forward to future research findings about 1462-37-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,1-Di-tert-butoxy-N,N-dimethylmethanamine

To a solution of 2,6-dichloroisonicotinic acid (2 g, 10.4 mmol) in toluene (50 mL) N,N dimethylformamide di-tert-butil acetal (15 mL, 62.5 mmol) was added under nitrogen atmosphere and mixture heated at 80 Ethyl acetate was added and organic layer was washed with water and brine, dried (MgSO4), filtered and concentrated to yield the title compound (2.34 g, 87%) as a solid.LRMS (m/z): 249 (M+1)+.1H NMR (400 MHz, CHLOROFORM-d) ppm 1.60 (s, 9 H) 7.74 (s, 2 H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 36805-97-7.

Electric Literature of 202865-80-3, These common heterocyclic compound, 202865-80-3, name is 4-Bromo-2-fluoro-1-isopropoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 2-amino-5-ethyl-3-(4-methylphenoxy)pyrazine (55.0 mg, 0.240 mmol) and dioxane (1 mL) were added 4-bromo-2-fluoro-1-isopropoxybenzene (61 mg, 0.26 mmol), tris(dibenzylideneacetone)(0) (2.8 mg, 0.0030 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (4.2 mg, 0.0072 mmol) and sodium phenoxide trihydrate (61 mg, 0.36 mmol), and the resulting mixture was heated at reflux for 4 hours. To the reaction mixture was added saturated aqueous sodium bicarbonate, and the mixture was extracted with ethyl acetate. The extract was washed by brine, dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified by reversed-phase HPLC (0.3% formic acid/acetonitrile) to give 5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine (17 mg, Yield: 18%)as pale brown solid. 1H-NMR (delta ppm TMS/DMSO-d6): 1.05 (3H, t, J = 7.5 Hz), 1.26 (6H, d, J = 5.8 Hz), 2.33 (3H, s), 2.44 (2H, q, J = 7.5 Hz), 4.45-4.52 (1H, m), 7.05-7.17 (3H, m), 7.25 (2H, d, J = 8.6 Hz), 7.55-7.61 (1H, m), 7.69 (1H, s), 7.85-7.91 (1H, m), 8.93 (1H, s).

Statistics shows that 4-Bromo-2-fluoro-1-isopropoxybenzene is playing an increasingly important role. we look forward to future research findings about 202865-80-3.

Application of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 16 Sodium perfluoro-2-methyl-3-oxahexanoate The procedure of Example 1 was followed using perfluoro-2-methyl-3-oxahexanoyl fluoride (16.6 g, 50 mmol), sodium trimethylsilanolate (5.6 g, 50 mmol), dry o-dichlorobenzene (200 mL), and 1 h at room temperature followed by rapid heating to 150. Sodium perfluoro-2-methyl-3-oxahexanoate (13.6 g, 77% yield) was isolated as a white solid: The 19 F NMR data were the same as reported in Example 15.

The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 321-28-8, name is 1-Fluoro-2-methoxybenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Fluoro-2-methoxybenzene

General procedure: An oven-dried 20 mL scintillation vial, equipped with a magnetic stir-bar, was charged with the starting material (1.0 equiv), DDQ (1.0 equiv), trifluoromethanesulfonic acid (1.4% v/v, 3.0 equiv), and 1,2-dichloroethane (0.05 M). The reaction mixture was then allowed to stir at ambient temperature for 10 h. After this time, methanol (0.05M) was added, and the solution was then allowed to stir at ambient temperature for an additional hour. Upon addition of the methanol, some solids precipitated out of the solution. Then, the solvent was removed from the heterogeneous mixture under reduced pressure. The crude material was purified by either recrystallization (methanol/DCM) or silica-gel column chromatography (hexanes/DCM) to give the title compounds.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 658-89-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-Aryl-5-trifluoromethoxybenzimidazole. The modified procedure of Bahrami, K. et. al. (Bahrami K., Khodaei M. M., Kavianinia I. Synthesis 2007, p. 547-550) was used. A solution of 2-amino-4-trifluoromethoxyaniline (0.7 g, 0.0036 Mol) in acetonitrile -CH3CN (5 mL) was mixed with aldehyde (0.0037 Mol) in CH3CN (5 mL) at 20 C. and stirred for 5-10 min. Aqueous 30% H2O2 (0.025 Mol) and concentrated 35% aqueous HCl (0.0126 Mol) were added at 20 C. and the mixture was stirred at this temperature for the 2-5 h (the progress of the reaction was monitored by TLC). Precipitate formed was filtered, washed with CH3CN (2×10 mL) and dried.2-Phenyl-5-trifluoromethoxybenzimidazole. Benzaldehyde was used, Ar=C6H5. Yield 0.76 g (71 wt. %). M.p. 208-210 C. 1H NMR (DMSO-d6): 7.31 (d, J=8.5 Hz, 1H), 7.38 (m, 2H), 7.49 (t, J=8.5 Hz, 1H), 7.83 (s, 1H), 7.95 (d, J=8.5 Hz, 1H), 8.57 (d, J=7.0 Hz, 2H). 13C NMR (DMSO-d6): 107.87, 115.26, 116.42, 120.21 (q, J=255.1 Hz), 126.90, 127.98, 128.84, 130.73, 135.91, 138.10, 144.17, 152.51. 19F NMR (DMSO-d6): -57.60. [M+1]+ 279.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Related Products of 29026-74-2,Some common heterocyclic compound, 29026-74-2, name is 2-Isopropoxyaniline, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-Hydroxynaphthalene-1-carboxylic acid or 1-hydroxynaphthalene-2-carboxylic acid (5.30 mmol) and appropriate alkoxyaniline (5.30 mmol) were suspended in 30 mL of dry chlorobenzene. Phosphorous trichloride (2.65 mmol) was added dropwise, and reacting mixture was heated in the microwave reactor for 15 min at 130 C using infrared flask-surface control of temperature. Solvent was evaporated in vacuum; residue solid was washed with 2M HCl and crystallized from aqueous ethanol. If necessary, column chromatography was used for further purification (mobile phase DCM:MeOH 19:1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Isopropoxyaniline, its application will become more common.