Synthetic Route of 7025-06-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7025-06-1 name is 1-Bromo-2-phenoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1-Bromo-diphenyl ether (9.8 g, 40 mmol) was added to a three-necked flask, stirred and dissolved with 200 mL of anhydrous tetrahydrofuran, protected with nitrogen, cooled to -78 C, then slowly added dropwise 2.5 M butyl lithium 16mL of solution, stir for half an hour after addingThen, a solution of 3-bromocarbazole (9.76 g, 40 mmol) in tetrahydrofuran was added dropwise to the reaction solution, and the mixture was added dropwise to room temperature, and the reaction was stirred for 2 hours.Quenched by adding a saturated ammonium chloride solution, adding a water solution, and concentrating the organic phase.A yellow oil was obtained. The oil was added to a mixture of 100 mL of HAc and 20 mL of HCl.After cooling, the organic phase was washed three times with DCM extraction of saturated brine.The solvent was evaporated and the residue was crystallised from DCM /EtOAc.The white solid was obtained as Compound 3-1 (13.4 g, yield 82%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-phenoxybenzene, and friends who are interested can also refer to it.