102-52-3, name is 1,1,3,3-Tetramethoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 102-52-3
Example 1: Ethyl fl2-Amino-3-chloro-6,7,10,ll-tetrahydro-7,ll- methanocycloocta[61 quinolin-9-yl)acetate (HUP 1)Preparation of tetramethyl 3,7-Dihydroxybicyclo[3.3.11nona-2,6-diene-2,4,6,8- tetracarboxylateA mixture of 1,1,3,3 tetramethoxypropane (32.8 g, 0.20 mol) and 2 M HC1(100 mL) was stirred for 1.5 h at room temperature. To this mixture cooled at 0C was added successively and carefully an aqueous solution of 5 M NaOH within 30 min (pH = 8) and MeOH (100 mL). At 0C, dimethyl-3-oxoglutarate (69.6 g, 0.40 mol) was added, followed by addition of MeOH (70 mL). The reaction mixture was allowed to warm to room temperature and stirred for 3 days. The reaction mixture was acidified to pH = 3 with 10 M HC1. Filtrating fractionwise, washing with water and drying at the dessicator afford the desired tetra ester as a white solid (39.2 g, 51%).
The synthetic route of 102-52-3 has been constantly updated, and we look forward to future research findings.