Related Products of 707-07-3, A common heterocyclic compound, 707-07-3, name is (Trimethoxymethyl)benzene, molecular formula is C10H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
l-(2-Chloro-acetyl)-2-oxo-2,3-dihydro-lH-indole-6-carboxylic acid methyl ester (220.0 g / 0.8219 mol) was suspended in toluene (1096.8 ml) at ambient temperature. Acetic anhydride (269.4 ml / 3.49 eq) was added and the mixture stirred at reflux. To the reaction, trimethyl orthobenzoate (339.10 ml / 2.40 eq) was added within one hour and the reaction continued to stir at 104 C for 3.5 hours and than at ambient temperature for 5 days. The reaction was cooled to 0C, stirred for an additional hour and filtered. The solid was washed with toluene, toluene/EtOAc (1 :1) and Et20 and dried under vacuum to isolate 246.6 g (77.8 %) of l-(2-chloro-acetyl)-3-[l-methoxy-l-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-lH- indole-6-carboxylic acid methyl ester.
The synthetic route of 707-07-3 has been constantly updated, and we look forward to future research findings.