Reference of 82830-49-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step A: A 3-neck 1-liter flask equipped with a low temperature thermometer, N2 line, and dropping funnel was charged with 1, 4-dimethoxy-2-fluorobenzene (20.42 g, 131 mmol). The solid was dissolved in distilled THE (450 mL) and cooled to an internal temperature of-74DEG C. A 2.5 M solution of n-BuLi in hexane (63 mL, 157 mmol) was subsequently added over 25 min. under N2 via a dropping funnel. The reaction was maintained at-75 DEGC for 30 min. , before adding solid sulfur (5.01 g, 157 mmol) in one portion. Nitrogen sparging of the reaction mixture was begun at this time and continued throughout the reaction. The internal temperature rose to-65 DEG C but quickly recooled to-75 DEG C. The reaction temperature was maintained at-75 DEG C for 30 min. At this time, the excess dry ice in the dry ice/acetone bath was removed and the reaction was allowed to slowly warm to-20 DEG C over 1.5 h. The reaction was quenched with 2 N HC1 with vigorous N2 bubbling until the color of the reaction turned pale yellow.The internal temperature of the reaction rose to 10 DEG C. The reaction was extracted with EtOAc. The organic layer was collected, washed with brine, dried over MgS04, filtered, and concentrated in vacuo. The yellow residue was purified by silica gel chromatography with 20% EtOAc/hexane as the eluant to give the desired product as a light yellow solid. 1H 600MHz NMR (CDC13) ppm (8) : 3.84 (s, 3H), 3.86 (s, 3H), 6.56 (dd, J=1.8 Hz, J=8.9 Hz, 1H), 6.70 (t, 1H).
The synthetic route of 2-Fluoro-1,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.