In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 588-96-5 as follows. Recommanded Product: 588-96-5
Example 2.1(2-{4-[1 -(4-Ethoxy-phenyl)-piperidin-4-yl1-phenyl)-1 -methyl-ethyl Vacetamide3.0 mL Toluene/tert-butanol (5:1 ) are added to a mixture of 130 mg (0.50 mmol) N-[1 – methyl-2-(4-piperidin-4-yl-phenyl)-ethyl]-acetamide (VIII.1 ), 100 mg (0.50 mmol) 1 – bromo-4-ethoxy-benzene, 80 mg (0.83 mmol) sodium tert-butyrat, 20 mg (0.040 mmol) X-Phos and 10 mg (0.040 mmol) palladium(ll) acetate. The mixture is stirred for 10 min at 150C under microwave irradiation in a sealed tube. After that time, the mixture is poured into 1 mL 0.1 N HCl . 1 mL cone, ammonia is added and the mixture is extracted with ethyl acetate (3x). The combined organic layers are dried over sodium sulphate and the solvent is removed in vacuo. The residue is purified by column chromatography (silica gel; DCM/MeOH 19:1 ) to yield the desired product. C2 H32N2O2 (M = 380.5 g/mol), ESI-MS: 381 [M+H]+
According to the analysis of related databases, 588-96-5, the application of this compound in the production field has become more and more popular.