Application of 3-Trifluoromethoxyaniline

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Trifluoromethoxyaniline, other downstream synthetic routes, hurry up and to see.

Related Products of 1535-73-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1535-73-5, name is 3-Trifluoromethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 3- (trifluoromethoxy) aniline (110 mg, 0.624 mmol), pyridine (151 muL, 1.87 mmol) in N, N- dimethylacetamide (3 mL) was added phenyl chloroformate (83.0 muL, 0.625 mmol) with stirring under ice-cooling, and the mixture was stirred at room temperature for 1 hr. 4- [ (5- Methyl-5H-pyrrolo [3, 2-d]pyrimidin-4-yl) oxy] aniline (100 mg, 0.416 mmol) was added to the reaction mixture, and the mixture was stirred at 900C for 15 hr. The reaction mixture was diluted with water, and extracted with ethyl acetate (chi3) . The organic layer was washed with saturated brine, dried over EPO anhydrous magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90->100/0) and recrystallized from ethyl acetate-hexane to give the title compound (74.6 mg, 40%) as a white solid.1H-NMR (DMSO-de, 300 MHz-) delta 4.09 (3H, s) , 6.57 (IH, d, J = 3.0 Hz), 6.93 (IH, d, J = 8.4 Hz), 7.22 (2H, d, J = 8.8 Hz), 7.29(IH, d, J = 8.4 Hz), 7.38 (IH, t, J = 8.4 Hz), 7.51 (2H, d, J = 8.8 Hz), 7.69 (IH, s), 7.75 (IH, d, J = 3.0 Hz), 8.25 (IH, s), 8.83 (IH, s), 9.01 (IH, br s) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Trifluoromethoxyaniline, other downstream synthetic routes, hurry up and to see.