A new synthetic route of 1-Bromo-3-methoxypropane

According to the analysis of related databases, 36865-41-5, the application of this compound in the production field has become more and more popular.

Application of 36865-41-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36865-41-5 as follows.

A 250 mL round-bottomed flask was charged with 5-bromo-2-chloro-phenol (22 g, 106 mmol), 1-bromo-3-methoxy-propane (19.5 g, 127 mmol), K2CO3 (30 g, 212 mmol) and DMF (50 mL). The resultant mixture was stirred at 50 C. for 3 hours, then ethyl acetate and water were added. The organic phase was separated, and then dried over anhydrous Na2SO4 and then concentrated to give 4-bromo-1-chloro-2-(3-methoxypropoxy)benzene (30 g).

According to the analysis of related databases, 36865-41-5, the application of this compound in the production field has become more and more popular.