Synthetic Route of 171290-52-1,Some common heterocyclic compound, 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Procedure A: To a solution of alkyne (1.3equiv.) and (E)-4-azido-bis(POM)-but-2-enylphosphonate 22 (0.11mmol, 1.0equiv.) in t-BuOH/ H2O (1:1 ratio, 400muL) were added Cu powder (11.6mg, 0.40mmol, 5.0equiv.) and CuSO4 (5.0mg, 0.020mmol, 0.25equiv.). The resulting suspension was stirred 8h at room temperature, then the crude mixture was diluted in EtOAc (1mL), and directly transferred on a preparative thin layer silica plate to give (E)-4?-(1,2,3-triazol-1-yl)-bis(POM)-but-2?-enylphosphonate.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethoxyphenylacetylene, its application will become more common.