These common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 645-36-3
4-(2-bromoethyl)heptane (4.14 g, 1.0 eq, 20 mmol) was dissolved in 30 mL of DMF and the amino acetal was added(2.66 g, 1.0 eq, 20 mmol) and K2CO3 (5.5 g, 2.0 eq, 40 mmol).After the reaction solution was reacted at 100 C. for 6 hours, the reaction was completed by TLC (PE:EA=1:1).The reaction solution was poured into water (50 mL) and extracted with ethyl acetate (50 mL x 3).The combined reaction solution was washed successively with saturated aqueous NH 4 Cl (50 mL×3), water (30 mL) and saturated brine (30 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to give the product as a yellow oil (4.2 g, Y=81.1%). .
The synthetic route of 2,2-Diethoxyethanamine has been constantly updated, and we look forward to future research findings.