Reference of 93-04-9,Some common heterocyclic compound, 93-04-9, name is 2-Methoxynaphthalene, molecular formula is C11H10O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A flame dried Schlenk flask was charged with Bi(OTf)3 (13.1 mg,0.020 mmol), alkyl aryl ethers (0.40 mmol), alcohols or thiols (1.2 mmol) andCH2ClCH2Cl (0.20 mL), and then the resulting mixture was stirred at 110 C (or 130 C forthe synthesis of 1m) for 24 h. The solvent was removed under the reduced pressure, andthe residue was subjected to flash column chromatography on silica gel with hexane /AcOEt as eluents to afford the corresponding aryl ethers or aryl thioethers
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxynaphthalene, its application will become more common.