Electric Literature of 1535-75-7,Some common heterocyclic compound, 1535-75-7, name is 2-(Trifluoromethoxy)aniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A Schlenk tube was charged with dibromides (0.3 mmol), Pd2dba3(0.0075 mmol), DPEPhos (0.03 mmol), and Cs2CO3 (0.75 mmol). The tube was evacuated and backfilled with argon before amine (0.36 mmol) and 2 mL toluene was added. The reaction mixture was stirred at 120 oC for 8-24h. After the reaction mixture was diluted with EtOAc and washed with water and brine, the solution was dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (eluting with 50:1 petroleum ether/ethyl acetate) to provide the desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethoxy)aniline, its application will become more common.