Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89521-55-1, name is 3-(Benzyloxy)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks
To a stirred solution of 3- benzyloxybenzene-1,2 -diamine (1 g, 4.67 mmol) in AcOH (20 mL) was added with tetramethoxymethane (0.95 g, 7 mmol) in one portion at 20 oC. The solution was stirred overnight. Then the mixture was concentrated in vacuo. The residue was purified by prep-HPLC (neutral condition) to afford 4-benzyloxy-2- methoxy-1H- benzimidazole (0.7 g, 56%) as a white powder. LCMS (M+H+) m/z: Calcd: 255.11; Found: 255.1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.