Synthetic Route of 41864-45-3,Some common heterocyclic compound, 41864-45-3, name is 4,5-Dimethoxy-2-methylaniline, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 76 N-(2-methyl-4,5-dimethoxyphenyl)cinnamamide To a solution of 4,5-dimethoxy-2-methylaniline (40.1 g), pyridine (48.5 ml), and acetone (350 ml), cinnamoyl chloride (44.0 g) was added dropwise at room temperature over 15 minutes. After allowing to react at room temperature for 2 hours, water (15 ml) was added and the mixture was stirred for 20 minutes. The solvent was distilled off under reduced pressure, and the residue was dissolved in chloroform, followed by washing with 1N HCl, 1N caustic soda and water in this order, and drying. Chloroform was evaporated. Precipitated crystals were collected by filtration with ether. 69.8 g of the title compound was obtained as yellow crystals (97.8%). 1 H-NMR(CDCl3)delta: 2.24(3H,s), 3.86(6H,s), 6.60(1H,d,J=15.1 Hz), 6.69(1H,s), 7.20(1H,bs), 7.37(3H,bs), 7.53(3H,bs), 7.75(1H,d,J=15.1 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,5-Dimethoxy-2-methylaniline, its application will become more common.
Reference:
Patent; Kowa Co., Ltd.; US5576324; (1996); A;,
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