Application of 1663-61-2, The chemical industry reduces the impact on the environment during synthesis 1663-61-2, name is (Triethoxymethyl)benzene, I believe this compound will play a more active role in future production and life.
The product of Example 33D (62 mg, 0.2 mmol) was treated with triethyl orthobenzoate (Aldrich, 0.5 ml_) in DMF (1 ml_) at 1000C for 10h. It was then concentrated. The title product was purified by preparative HPLC (Xterra.(TM)., column, Xterra RP-18, 5 mum, 30 x 100 mm. Eluting Solvent, MeCN / H2O (NH4HCO3, 0.1 M, pH=10), (v. 90/10 to 10/90 over 20 min.) Flow rate, 75 mL/min., uv, 250 nm) as solid (40.0 mg, 50percent). 1H NMR (500 MHz, CD3OD) delta 1.52 – 1.64 (m, 1 H), 1.68 – 1.80 (m, 1 H), 1.80 – 1.92 (m, 1 H), 2.06 – 2.18 (m, 1 H), 2.25 – 2.31 (m, 1 H), 2.75 – 3.10 (m, 5 H), 3.39 – 3.49 (m, 1 H), 5.14 – 5.27 (m, 1 H), 7.55 – 7.66 (m, 3 H), 7.69 (dd, J=8.5, 1.8 Hz, 1 H), 7.81 (d, J=8.2 Hz, 1 H), 8.00 (d, J=1.5 Hz, 1 H), 8.27 (dd, J=8.1 , 1.7 Hz, 2 H), 8.89 (s, 2H) ppm; MS (DCI/NH3): 399 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Triethoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ABBOTT LABORATORIES; WO2006/65233; (2006); A1;,
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