Related Products of 111-95-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-95-5, name is Bis(2-methoxyethyl)amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To the product from step 46 2 (116 mg, 0.19 mmol) was added 43 bis(2-methoxylethyl)amine (3.0 mL, 2.71 g, 20.3 mmol) and a ?spatula tip? of Pd(PPh3)4. The resulting mixture was heated to 140 C. for 2 h. The reaction was cooled and concentrated. The residue was purified by flash chromatography (SiO2, 10/1 CHCl3-MeOH). The resulting 47 material was purified again by reverse phase medium pressure chromatography (C18, 10-50% manual gradient acetonitrile in 0.1% TFA) to afford 12 mg (10% yield) of Example 4 as an orange-brown film: LCMS (15-95% gradient acetonitrile in 0.1% TFA over 10 min), single peak retention time=3.85 min on 250 mm column, (M+H)+=661. UV/vis (100 ?M in PBS) ?abs=434 nm. Fluorescence ?ex=449 nm, ?em=559 nm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Bis(2-methoxyethyl)amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MediBeacon Inc.; Debreczeny, Martin P.; Rajagopalan, Raghavan; Dorshow, Richard B.; Neumann, William L.; Rogers, Thomas E.; (54 pag.)US2019/125901; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem