Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36865-41-5, name is 1-Bromo-3-methoxypropane, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H9BrO
A solution of compound of Formula-Ill (lOOg) in toluene (600 ml) and Dimethylsulfoxide (60 ml) was added to potassium carbonate (185g) and l-Bromo-3-methoxypropane (130g) at 25-30C. The resulting reaction mixture was stirred at 85- 90C for 16h. After cooling, the solid was filtered and washed with water. The toluene layer of compound of Formula-IV was cooled to 0-5C and sodium borohydride (9gm) was added. To this reaction mixture methanol (50 ml) was added drop wise at 0-5C over a period of lh and stirred the reaction mixture at the same temperature for 2h. The reaction was quenched with dilute hydrochloric acid and stirred for 30 minutes. pH of the reaction mixture was adjusted to 7.0-7.5 with aq. Sodium hydroxide solution. Organic layer was separated and aqueous layer was extracted with toluene. Combined organic layers were dried and evaporated under reduced pressure to give compound of Formula- IV as residue. The residue was dissolved in dichloromethane and added to a solution of thionyl chloride in dichloromethane at 0-5C over a period of lh and stirred the reaction mixture at the same temperature for 2h. Dichloromethane was distilled under reduced pressure at 30-35C till no more distillate was collect. The compound was re-crystallized in hexanes to give tile compound as white solid. Yield: 125g; GC purity: 99%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MYLAN LABORATORIES LIMITED; RAMA, Shankar; VADALI, Lakshmana Rao; MANUKONDA, Seshadri rao; POTLA, Venkata Srinivas Rao; VADLAMUDI, Mohana Vamsi Krishna; DASARI, Srinivasa Rao; WO2013/171767; (2013); A1;,
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