Synthetic Route of 1836-62-0,Some common heterocyclic compound, 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 9.7 g 4-(OXIRANE-2-YLMETHOXY)-9H-CARBAZOLE (II), 53.7 g of anhydrous hydrogen sulphate of 2-(2-METHOXYPHENOXY) ETHYLAMINE (III) and 28 g of anhydrous potassium carbonate in 200 ML ISOPROPANOL are, with intensive stirring, heated at 80 C for six hours. When the epoxide has reacted, the mixed salts are filtered off from the reaction mixture and isopropanol is distilled off from the filtrate. The obtained honey-like concentrate is diluted with heating in 50 ml of ethylacetate, the solution is cooled to the temperature of 40 C, it is inoculated and stirred at the temperature of 40 C for two hours. After the crystal precipitates, the mixture is cooled to the temperature of 0 C, and is kept like that with stirring for a minimum of four hours. After filtration and washing with cooled ethylacetate, 5.2 g of wet, crude Carvedilol is obtained (HPLC contents 95.2 area %, HPLC contents of the bis-derivative 2.8 area %).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Methoxyphenoxy)ethylamine, its application will become more common.
Reference:
Patent; Zentiva, A.S.; WO2004/41783; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem