Electric Literature of 6943-97-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
(16-3) Synthesis of [5-(2-{4-[3-(3-methoxyphenyl)propoxy]-3-trifluoromethylphenyl}ethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamic acid t-butyl ester (compound 16-3) Reference Example compound 2-6 (500 mg) was dissolved in N,N-dimethylformamide (10 ml), potassium carbonate (493 mg) and compound 16-2 (328 mg) were added, and the mixture was stirred at 80C for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate, washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (800 mg) as a white solid. 1H-NMR(CDCl3) delta (ppm): 1.42(3H, s), 1.44(3H, s), 1.47(9H, s), 1.93-1.98(2H, m), 2.08-2.12(2H, m), 2.51-2.56(2H, m), 2.81(2H, t, J=7.5Hz), 3.69(2H, d, J=11.7Hz), 3.76(3H, s), 3.89(2H, d, J=11.7Hz), 3.99(2H, t, J=6.0Hz), 4.98(1H, brs), 6.72-6.84(4H, m), 7.19(1H, t, J=7.5Hz), 7.24(1H, d, J=1.8Hz), 7.36(1H, d, J=1.8Hz).
The chemical industry reduces the impact on the environment during synthesis 1-(3-Bromopropyl)-3-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
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