Electric Literature of 150-78-7, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 150-78-7, Name is 1,4-Dimethoxybenzene, SMILES is COC1=CC=C(OC)C=C1, belongs to ethers-buliding-blocks compound. In a article, author is Rui, Yuefan, introduce new discover of the category.
Molecular dynamics and spectral analysis for the binding of methoxylated polybrominated diphenyl ethers to lysozyme
The interaction between three methoxylated polybrominated diphenyl ethers (MeO-PBDEs) and lysozyme was investigated using two complementary techniques: computational simulations and multi-spectroscopic methods. Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) method was used to determine the relative binding energies. Molecular modeling analysis showed van der Waals and hydrogen bonding forces as the major forces responsible for interactions between compounds and Lysozymes. The binding site for 2′-MeO-BDE-3 and 5-MeO-BDE-47 in lysozyme was determined to be at the active pocket, where these ligands bound strongly with lysozyme tryptophan (TRP) residues TRP62, TRP63 and GLU35. In the 3-MeO-BDE-100-lysozyme system, F-shaped and T-shaped interactions between ligand and TRP62 (TRP108) were present, which suggested the stability of the combination. Fluorescence lifetime measurements suggested that be interactions between MeO-PBDEs and lysozyme could be present, and the microenvironment around the TRP residues was slightly altered during the binding process. Circular dichroism (CD) spectroscopy and UV-vis absorption spectra revealed interactions between lysozyme and MeO-PBDEs, thus inducing changes in the lysozyme microenvironment and an increase in its content of alpha-helix structures. (C) 2020 Elsevier B.V. All rights reserved.
Electric Literature of 150-78-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 150-78-7 is helpful to your research.