Month: April 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 446-61-7, name is 2-Fluoro-6-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Fluoro-6-methoxyaniline

(1) 2-Fluoro-6-methoxyaniline (7.80 g) and 17.23 g of di-(2-bromoethyl)amine hydrobromide were dissolved in 5 ml of water and, by heating at about 110 C. on a bath, 10 ml of 30% potassium hydroxide solution was added thereto (each about 3.5 ml once an hour). Heating was further continued (7 hours in total). After cooled, the reaction solution was made alkaline with aqueous solution of sodium hydroxide to salt out and extracted with chloroform twice. The extract was washed with saturated sodium chloride solution, dried over sodium sulfate, the solvent was evaporated therefrom, and the residue was purified by a column chromatography to give 8.95 g of oily 1-(2-fluoro-6-methoxyphenyl)piperazine in 34.93 g yield or 94%.

According to the analysis of related databases, 446-61-7, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2-Methoxyphenoxy)ethylamine

(f) A mixture comprising 2-(2-methoxyphenoxy)ethylamine (10 g, 59.9 mmol), diisopropylethylamine (13.9 mL, 81.6 mmol) and dichloromethane (80 mL) was cooled to 0 C. and then a solution of 3-methoxy-4-nitrobenzoyl chloride (11.76 g, 54.4 mmol) in dichloromethane (50 mL) was added dropwise. The mixture was allowed to warm to 23 C. over two hours, quenched with aqueous hydrochloric acid (3M, 20 mL), washed with water (3*20 mL), dried (Na2SO4) and concentrated in vacuo to provide N-[2-(2-methoxyphenoxy)ethyl]-3-methoxy-4-nitrobenzamide (14 g, 74% yield) an off white solid; MS (PB-PCI) C17H18N2O6 m/e calc 346.34; found 347 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 450-91-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 450-91-9, name is 4-Fluoro-2-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

iii: Intermediate 3 (1.0 eq) and cesium carbonate (2.0 eq) and corresponding phenylamine (1.2 eq) were added into a dry reaction flask. Dry DMF was used as reaction solvent, N2 was used to remove water vapor and oxygen. Then catalyst and ligand Pd(AcO)2 (0.1 eq) and Xantphos (0.1 eq) were added. The reaction mixture was transferred to a 60 C oil bath, 6~7 hours. After the reaction completed, the mixture was filtered and evaporated. Intermediate 4 was gained. The yield was 50%.

The synthetic route of 4-Fluoro-2-methoxyaniline has been constantly updated, and we look forward to future research findings.

Synthetic Route of 106854-77-7, A common heterocyclic compound, 106854-77-7, name is 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene, molecular formula is C8H6BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 7: 1-Benzyl-N,4-dimethyl-N-neopentyl-3-(4-(2,2,2-trifluoroethoxy)phenyl)-5-(trifluoromethyl)-1H-pyrrole-2-carboxamide (SC-260) Under an nitrogen atmosphere 1-benzyl-N,4-dimethyl-N-neopentyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrrole-2-carboxamide (106 mg, 0.216 mmol) was dissolved in DMF (1 mL) and LiOH (4 mg, 0.216 mmol), bis(tri-tert-butylphosphine)palladium (0) (6 mg, 0.014 mmol) and 1-bromo-4-(2,2,2-trifluoroethoxy)benzene (50 mg, 0.196 mmol) were subsequently added. The reaction mixture was stirred at 80 C. under microwave irridation for 1 h. The mixture was cooled to RT and the reaction was stopped by addition of 1M NaOH solution (2 mL). The crude product was extracted with EtOAc (2*3 mL) and the combined organic layers were washed with water (3*1 mL), dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The crude mass was purified by flash chromatography to give SC-260 (95 mg, 89.7%).

The synthetic route of 106854-77-7 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene, molecular formula is C8H8BrFO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-(2-Bromoethoxy)-4-fluorobenzene

A solution of 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid benzylamide (0.2 g, 0.67 mmol) in dimethyl sulfoxide (5 mL) was treated with 4-fluorophenoxyethyl bromide (0.14 g, 0.67 mmol) and potassium carbonate (0.30 g, 2.0 mmol), and the reaction mixture was heated to 90 0C for 16 hr. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (50 mL), and washed with brine (2 x 50 mL). The organic phase was dried (Na2SC^) and evaporated. The residue was purified by preparative thin layer chromatography over silica gel (methylene chloride:methanol, 95:5) to provide 2-{l-[2-(4-fluoro-phenoxy)-ethyl]-lH-pyrazol-3-yl}-4-methyl-thiazole- 5-carboxylic acid benzylamide (0.071 g, 51% yield) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 332-48-9, its application will become more common.

Electric Literature of 162705-07-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: DCC (0.47 mmol, 1.2 eq.); the N-Fmoc-protected amino acid (0.472 mmol, 1.2 eq) and HOBt·H2O (0.47 mmol, 1.2 eq) were added to a solution of the 30-aminocombretastatin (0.39 mmol, 1 eq) in anhydrous DMF (1.3 mL). The reaction mixture was stirred under N2 atmosphere for 16 h. Then, it was ltered, and the ltrate was poured into a saturated aqueous NH4Cl solution and then extracted with AcOEt (3×15 mL). The combined organic extracts were washed 2 times with water and brine and dried over anhydrous MgSO4. After ltration and evaporation of the solvent under reduced pressure, the resulting residue was chromatographed on silica gel with Hexanes-AcOEt (6:4) to aord the corresponding N-Fmoc-protected derivatives 7 and 9.

The synthetic route of (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 54149-17-6

To a vial containing ethyl 1H-indazoie-3-carboxyiate (150 mg, 0.789 inmol) in C1-I3CN (3 mL), were added I -bromo-2-(2-methoxyethoxy)etharie (217 mg, 1.183 mniol) and Cs?C03 (385 mg, 1.183 mrnol). The vial was sealed and the mixture was stirred at 80C overnight. Afterwards, water was added, extracted with EtOAc, washed organic layer with 10% LiCI, brine, concentrated and the residue was purified by normal phase chromatography with the second peak to elute off column being the desired product (105mg, 40.5%). MS (ESI) m/?: 293.2 (M±HY?. ?H NMR (400MHz, CDCI3) 5 8.20 (dt, J::r8.2,1.0 Hz, IH), 7.63- 7.57(m, 1H), 7.42 (ddd, J=8.4, 7.0, 1.1 Hz, IH), 7.30 (ddd, J=8.1,7.0, 0.9 Hz, 1H), 4.67 (t, J=5.6 Hz, 2H), 4.53 (q, J:::73 Hz, 21-1), 3.97 (t, J:::57 Hz. 21-1),3.56 – 3.48 (rn, 2H). 343 – 337 (m, 2H), 3.28 (s, 31:1), 1.48 (t, J:::7.2 Hz,3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54149-17-6.

Synthetic Route of 1579-40-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1579-40-4, name is Di-p-tolyl Ether, This compound has unique chemical properties. The synthetic route is as follows.

20 g (0.1 mol) of 4,4′-dimethyl diphenyl ether,60 g of carbon tetrachloride and 0.82 g (0.005 mol) of azoisobutyronitrile were charged into the above four-necked flask,Heating the material through a water bath,After heating to 80 C with stirring, 36.8 g (0.23 mol) of bromine was added dropwise,1.1h drop finished,After the drop-back reaction 3.0h.The reaction liquid obtained by the refluxing reaction was subjected to atmospheric distillation of carbon tetrachloride,The material was then cooled to 50 & lt; 0 &To the cooled mass was added 98.4 g (0.3 mol) of a 25% solution of sodium isopropoxide in isopropanol,35min drop finished,Heating reflux 3.0h,The isopropanol was then distilled off.The carbon tetrachloride vaporization was 54.8 g,After washing to neutral and dry after carbon tetrachloride 54.2g,The purity was 99.1% by gas chromatography analysis,The recovery was 90.3%.The amount of isopropanol distilled off was 67.1 g,The purity was 95.6% by gas chromatography,The recovery was 86.9%.Recovery of isopropyl alcohol by distillation and drying dehydration can be used for sodium isopropoxide system.100 mL of water was added to the above materials,Stirring 10min after standing phase,The oil phase was washed twice with the remaining water,Each wash water 50mL.The washed oil phase is first distilled off under normal pressure,And then under a pressure of 1 ~ 2mmHg vacuum distillation,To obtain 23.8 g of a crude product having a boiling point of 220 to 230 C / 1 to 2 mmHg.After the crude product is obtained, the crude product is subjected to vacuum distillation treatment in the present invention to obtain pure product. The product purity was 99.8% by gas chromatography. The yield was calculated to be 92.8%.

The chemical industry reduces the impact on the environment during synthesis Di-p-tolyl Ether. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 321-28-8, name is 1-Fluoro-2-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 321-28-8, name: 1-Fluoro-2-methoxybenzene

A stirred solution of 2-fluoroanisole (33.7 mL, 301 MMOL) in chloroform (250 mL) was cooled to 0C and treated drop-wise with chlorosulfonic acid (50.0 mL, 752 MMOL). After stirring at room temperature for 14 hours, the reaction mixture was poured into ice-water (700 mL) and the separated, aqueous phase extracted with chloroform (2 x 200 mL). The combined organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated IN VACUO TO YIELD 3-FLUORO-4- METHOXYBENZENESULFONYL CHLORIDE as a fine, white solid (58.6 g, 87%), m. p. 80C ; 1H NMR (400 MHz, DMSO-d6) 5 : 7.32 (m, 1H), 7.25 (dd, J= 11.5, 2.0 Hz, 1H), 7.05 (t, J = 8. 5 HZ, 1 H), 3.78 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

These common heterocyclic compound, 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5414-19-7

TERT-BUTYL F [S- (4-BUTOXYPHENYL) thien-2-yl] sulfonyl} acetate (5) from Part C (4.0 g, MW 410.55), 18-CROWN-6 (from Aldrich, 0.5 g, catalytic amount), potassium carbonate (from Aldrich, 5.4 g, MW 138. 21,4. 0 eq), and bis (bromoethyl) ether (from Aldrich, 3.4 g, MW 231.93, 1.5 eq) were slurried in N, N-dimethylformamide (20 ML). The resulting mixture was stirred at 65C for 15 hr. Afterward, the mixture was diluted with water (50 ml) and extracted with ethyl acetate (3x-100 ml). The organics were combined and washed with water (2x), washed with brine (LX), dried over NA2S04, and concentrated for a tan oil. The oil was washed with hexanes and dried to afford tert-butyl-4-{[5-(4-butoxyphenyl) thien-2- yl] SULFONYL} TETRAHYDRO-2H-PYRAN-4-CARBOXYLATE (6) as a tan oil (4.3 g, 91 % YIELD). 1H NMR and LCMS confirmed the presence of the desired compound (6). The”equivalents” above indicate equivalents relative to the charged amount of tert-butyl {[5-(4- butoxyphenyl) thien-2-yl] sulfonyl} acetate.

The synthetic route of 1-Bromo-2-(2-bromoethoxy)ethane has been constantly updated, and we look forward to future research findings.