Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C7H7BrO, 2398-37-0, Name is 1-Bromo-3-methoxybenzene, molecular formula is C7H7BrO, belongs to ethers-buliding-blocks compound. In a document, author is Nordeman, P., introduce the new discover.
F-18-Radiolabeling and Preliminary Evaluation of a HSP90 ligand
Purpose: With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), we developed and preliminary validated a novel fluorine-18 labelled HSP90 ligand. Methods: A precursor containing methoxymethyl ethers protecting groups and a tosyl as leaving group was synthesized. The target compound was labeled with nucleophilic F-18-fluoride and the protecting groups was subsequently removed with hydrochloric acid before purification. In vitro cell- and frozen section autoradiography and in vivo animal studies were performed. Results: The precursor was successfully synthesized and utilized in the F-18-radiolabeling giving 0.5-1.0 GBq of pure product with a synthesis time of 70 min. In vitro experiments indicated a high specific binding, but in vivo studies showed no tumor uptake due to fast hepatobiliary metabolism and excretion. Conclusions: Despite the unfavorable in vivo properties of the tracer, the promising results from in vitro auto radiography experiments in frozen sections of P-NETs from surgical resection encourage us to continue the project aiming the improvement of in vivo properties of the tracer.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2398-37-0. Formula: C7H7BrO.